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Postnatal feeding with high-fat diet induces obesity and precocious puberty in C57BL/6J mouse pups: a novel model of obesity and puberty

Rahim Ullah, Yan Su, Yi Shen, Chunlu Li, Xiaoqin Xu, Jianwei Zhang, Ke Huang, Naveed Rauf, Yang He, Jingjing Cheng, Huaping Qin, Yu-Dong Zhou, Junfen Fu

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 266-276 doi: 10.1007/s11684-017-0530-y

Abstract:

Childhood obesity and obesity-related metabolic complications are induced by a high-fat postnatal diet. The lack of a suitable animal model, however, remains a considerable challenge in obesity studies. In the current study, we provided high-fat diet (HFD) to dams during lactation and to pups after weaning. We also developed a novel model of C57BL/6J mouse pups with HFD-induced postnatal obesity. Results showed that feeding with HFD induces fat deposition and obesity in pups. Furthermore, HFD more potently increased the body weight (BW) of male than female pups. HFD-fed female pups were obese, underwent precocious puberty, and showed increased kisspeptin expression in the hypothalamus. However, parental obesity and precocious puberty exerted no synergistic effects on the HFD-induced postnatal weight gain and puberty onset of the pups. Interestingly, some HFD-fed litters with normal BW also exhibited precocious puberty. This finding suggested that diet composition but not BW triggers puberty onset. Our model suggests good construction validity of obesity and precocious puberty. Furthermore, our model can also be used to explore the mutual interactions between diet–induced postnatal childhood obesity and puberty.

Keywords： postnatal HFD feeding     obesity     kisspeptin     HPG axis     precocious puberty    

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Five-axis rough machining for impellers

Ruolong QI, Weijun LIU, Hongyou BIAN, Lun LI

Frontiers of Mechanical Engineering 2009, Volume 4, Issue 1,   Pages 71-76 doi: 10.1007/s11465-009-0010-4

Abstract: The tool axis vector is confirmed based on flank milling using a simple method that could eliminate global

Keywords： five-axis     impeller     tool-path     planning     flank milling     ruled surface    

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Kinematic error separation on five-axis NC machine tool based on telescoping double ball bar

Min WANG, Jianzhong HU, Tao ZAN

Frontiers of Mechanical Engineering 2010, Volume 5, Issue 4,   Pages 431-437 doi: 10.1007/s11465-010-0110-1

Abstract: homogeneous transformation matrix (HTM) method are applied in establishing the kinematic error model of five-axismachining tool with two-axis turntable.Based on this model, a new method for the kinematic error separation in five-axis numerical control (In this study, three types of simultaneous three-axis control motions are designed for each rotary axisIn the measurement, two translational axes and one rotary axis are simultaneously controlled to keep

Keywords： error modeling     error separation     telescoping double ball bar     five-axis numerical control (NC) machining    

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Optimization model for rotor blades of horizontal axis wind turbines

LIU Xiong, CHEN Yan, YE Zhiquan

Frontiers of Mechanical Engineering 2007, Volume 2, Issue 4,   Pages 483-488 doi: 10.1007/s11465-007-0084-9

Abstract: This paper presents an optimization model for rotor blades of horizontal axis wind turbines.

Keywords： population     extended     algorithm     developed optimization     accurate    

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Application of Porous Aerostatic Bearings in Three-axis Table

Du Jinming

Strategic Study of CAE 2005, Volume 7, Issue 1,   Pages 65-68

Abstract: Three-axis table is the equipment that has high precision and is used to check, demarcate and establish

Keywords： aerostatic bearings     porous     orifice restricted     three-axis table    

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Performance of vertical axis water turbine with eye-shaped baffle for pico hydropower

Zhuohuan HU, Dongcheng WANG, Wei LU, Jian CHEN, Yuwen ZHANG

Frontiers in Energy 2022, Volume 16, Issue 4,   Pages 683-696 doi: 10.1007/s11708-020-0689-9

Abstract: A series of inline pico hydropower systems, which could be used in confined space, especially for water distribution networks (WDNs), was designed and investigated. The turbine with an eye-shaped vertical water baffle was developed to evaluate the hydraulic performance. A three-dimensional dynamic mesh was employed and the inlet velocity was considered as the inlet boundary condition, whereas the outlet boundary was set as the outflow. Then, numerical simulations were conducted and the standard turbulence model was found to be the best capable of predicting flow features through the comparison with the experimental results. The effects of the opening diameter of the water baffle and installation angle of the rotor on the flow field in the turbine were investigated. The results suggested that the water baffle opening at = 30 mm and the rotor at a 52° angle could achieve the highest efficiency of 5.93%. The proper eye-shaped baffle not only accelerates the fluid flow and generates positive hydrodynamic torque, but also eliminates the flow separation. The scheme proposed in this paper can be exploited for practical applications in the water pipelines at various conditions and power requirements.

Keywords： vertical axis water turbine     eye-shaped     vertical water baffle     pico hydropower    

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Determination of the feasible setup parameters of a workpiece to maximize the utilization of a five-axis

Aqeel AHMED, Muhammad WASIF, Anis FATIMA, Liming WANG, Syed Amir IQBAL

Frontiers of Mechanical Engineering 2021, Volume 16, Issue 2,   Pages 298-314 doi: 10.1007/s11465-020-0621-3

Abstract: The maximum utilization of five-axis machine tools depends upon the cutting system’s geometry, the configurationa mathematical model has been developed to determine the workpiece’s feasible location in the five-axisavoiding the number of iterations, which are usually performed to eliminate the global collision and axisIn this research, a generic arrangement of the five-axis machine tool has been selected.

Keywords： workpiece setup parameter     five-axis     space utilization     setup parameters     machine tool    

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Role of the forkhead transcription factor FOXO-FOXM1 axis in cancer and drug resistance

Fung Zhao, Eric W.-F. Lam

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 376-380 doi: 10.1007/s11684-012-0228-0

Abstract: An understanding of the role and regulation of the FOXO-FOXM1 axis will impact directly on our knowledge

Keywords： FOXO3a     FOXM1     transcription factor     cancer     drug resistance     tumorigenesis    

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Estimation of power in low velocity vertical axis wind turbine

Sampath S. S.,Sawan SHETTY,Chithirai Pon Selvan M.

Frontiers of Mechanical Engineering 2015, Volume 10, Issue 2,   Pages 211-218 doi: 10.1007/s11465-015-0338-x

Abstract:

The present work involves in the construction of a vertical axis wind turbine and the determination

Keywords： wind turbine     shaft design     power generation     generator    

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FMO3--TMAO axis modulates the clinical outcome in chronic heart-failure patients with reduced ejection

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 295-305 doi: 10.1007/s11684-021-0857-2

Abstract: The association among plasma trimethylamine-N-oxide (TMAO), FMO3 polymorphisms, and chronic heart failure (CHF) remains to be elucidated. TMAO is a microbiota-dependent metabolite from dietary choline and carnitine. A prospective study was performed including 955 consecutively diagnosed CHF patients with reduced ejection fraction, with the longest follow-up of 7 years. The concentrations of plasma TMAO and its precursors, namely, choline and carnitine, were determined by liquid chromatography-mass spectrometry, and the FMO3 E158K polymorphisms (rs2266782) were genotyped. The top tertile of plasma TMAO was associated with a significant increment in hazard ratio (HR) for the composite outcome of cardiovascular death or heart transplantation (HR=1.47, 95% CI=1.13–1.91, P=0.004) compared with the lowest tertile. After adjustments of the potential confounders, higher TMAO could still be used to predict the risk of the primary endpoint (adjusted HR=1.33, 95% CI=1.01–1.74, P=0.039). This result was also obtained after further adjustment for carnitine (adjusted HR=1.33, 95% CI=1.01–1.74, P=0.039). The FMO3 rs2266782 polymorphism was associated with the plasma TMAO concentrations in our cohort, and lower TMAO levels were found in the AA-genotype. Thus, higher plasma TMAO levels indicated increased risk of the composite outcome of cardiovascular death or heart transplantation independent of potential confounders, and the FMO3 AA-genotype in rs2266782 was related to lower plasma TMAO levels.

Keywords： chronic heart failure     trimethylamine-N-oxide     flavin monooxygenase 3     single nucleotide polymorphism    

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Chidamide inhibits the NOTCH1-MYC signaling axis in T-cell acute lymphoblastic leukemia

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 442-458 doi: 10.1007/s11684-021-0877-y

Abstract: In particular, chidamide inhibits the NOTCH1-MYC signaling axis by down-regulating the level of the intracellular

Keywords： T-cell acute lymphoblastic leukemia     HDAC inhibitor     chidamide     NOTCH1     MYC     ubiquitination    

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Effects of parenteral nutrition with and without GH on the GH/IGF-1 axis after hepatectomy in hepatocellular

CAO Jie, LUO Shimin, LIANG Lijian, LAI Jiaming, CHEN Shanming

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 287-293 doi: 10.1007/s11684-007-0055-x

Abstract: Complex alterations in the GH/IGF-1 axis are thought to play an important role in the protein catabolismexplore the effects of parenteral nutrition (PN) with and without growth hormone (GH) on the GH/IGF-1 axisThese data indicate that rhGH+PN could ameliorate the changes in the GH/IGF-1 axis after hepatectomy

Keywords： control     function     production     surgical     Complex    

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Electrostatic Spring Effect Analysis and Experimental Validation of Silicon Micromechanical Vibrating zaxis

Xia Dunzhu,Zhou Bailing,Wang Shourong

Strategic Study of CAE 2007, Volume 9, Issue 8,   Pages 66-68

Abstract: justify;">The error principle caused by structural process imperfection of silicon micromechanical z-axiscomputing the relation between the resonant frequency and feedback force added on the sense mode of MEMS z-axisgyroscope,  the inner relation between the ne gative electrostatic spring coefficient in sense axis

Keywords： silicon micromechanical z-axis gyroscope     negative electrostatic spring constant     feedback force generator    

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Atypical pituitary hormone–target tissue axis

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 1-17 doi: 10.1007/s11684-022-0973-7

Abstract: organs were summarized, defined by the novel concept of an “atypical pituitary hormone–target tissue axisThe continued exploration of the physiology of the “atypical pituitary hormone–target tissue axis” could

Keywords： thyroid-stimulating hormone     follicle-stimulating hormone     luteinizing hormone     adrenocorticotrophic hormone     prolactin    

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Analysis and characterization of wind-solar-constant torque spring hybridized model

Shantanu ACHARYA,Subhadeep BHATTACHARJEE

Frontiers in Energy 2014, Volume 8, Issue 3,   Pages 279-289 doi: 10.1007/s11708-014-0312-z

Abstract: In the proposed scheme, wind energy is harnessed by a hybrid vertical axis wind turbine, solar energy

Keywords： hybrid vertical axis wind turbine     Stirling engine     solar-thermal energy     wind energy     constant torque spring    

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Title Author Date Type Operation

Postnatal feeding with high-fat diet induces obesity and precocious puberty in C57BL/6J mouse pups: a novel model of obesity and puberty

Rahim Ullah, Yan Su, Yi Shen, Chunlu Li, Xiaoqin Xu, Jianwei Zhang, Ke Huang, Naveed Rauf, Yang He, Jingjing Cheng, Huaping Qin, Yu-Dong Zhou, Junfen Fu

Journal Article

Five-axis rough machining for impellers

Ruolong QI, Weijun LIU, Hongyou BIAN, Lun LI

Journal Article

Kinematic error separation on five-axis NC machine tool based on telescoping double ball bar

Min WANG, Jianzhong HU, Tao ZAN

Journal Article

Optimization model for rotor blades of horizontal axis wind turbines

LIU Xiong, CHEN Yan, YE Zhiquan

Journal Article

Application of Porous Aerostatic Bearings in Three-axis Table

Du Jinming

Journal Article

Performance of vertical axis water turbine with eye-shaped baffle for pico hydropower

Zhuohuan HU, Dongcheng WANG, Wei LU, Jian CHEN, Yuwen ZHANG

Journal Article

Determination of the feasible setup parameters of a workpiece to maximize the utilization of a five-axis

Aqeel AHMED, Muhammad WASIF, Anis FATIMA, Liming WANG, Syed Amir IQBAL

Journal Article

Role of the forkhead transcription factor FOXO-FOXM1 axis in cancer and drug resistance

Fung Zhao, Eric W.-F. Lam

Journal Article

Estimation of power in low velocity vertical axis wind turbine

Sampath S. S.,Sawan SHETTY,Chithirai Pon Selvan M.

Journal Article

FMO3--TMAO axis modulates the clinical outcome in chronic heart-failure patients with reduced ejection

Journal Article

Chidamide inhibits the NOTCH1-MYC signaling axis in T-cell acute lymphoblastic leukemia

Journal Article

Effects of parenteral nutrition with and without GH on the GH/IGF-1 axis after hepatectomy in hepatocellular

CAO Jie, LUO Shimin, LIANG Lijian, LAI Jiaming, CHEN Shanming

Journal Article

Electrostatic Spring Effect Analysis and Experimental Validation of Silicon Micromechanical Vibrating zaxis

Xia Dunzhu,Zhou Bailing,Wang Shourong

Journal Article

Atypical pituitary hormone–target tissue axis

Journal Article

Analysis and characterization of wind-solar-constant torque spring hybridized model

Shantanu ACHARYA,Subhadeep BHATTACHARJEE

Journal Article